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Expert Opin Drug Metab Toxicol 4: Application of high-content analysis to explore functional endpoints of cytotoxicity in primary cultures of hepatocytes. Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam and midazolam in adenoviral P transfected HepG2 cells and comparison with hepatocytes and in vivo. Hepatocytes the choice to investigate drug metabolism and toxicity in man:

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